I. Cytopathologic Physiologic Diagnostic and Clinical Aspects of Retinal Degeneration. - 1. Histochemical Comparison of Ocular Drusen in Monkey and Human. - 2. TIMP-3 Accumulation in Bruch's Membrane and Drusen in Eyes from Normal and Age-Related Macular Degeneration Donors. - 3. Photoreceptor Rosettes in Age-Related Macular Degeneration Donor Tissues. - 4. Central Retinal Sensitivity Repeated Measurements as Long Term Follow-up in Retinitis Pigmentosa. - 5. Complete and Incomplete Type Congenital Stationary Night Blindness (CSNB) as a Model of OFF-Retina and ON-Retina. - 6. A Family with X-Linked Cone Dystrophy Showing a Tapetal-like Reflex. - 7. Autoimmune Retinopathy: Cystoid Macular Edema in Retinitis Pigmentosa Patients. - 8. Norrie Disease in Japan. - II. Animal Models of Retinal Degeneration. - 9. Development of a Model for Macular Degeneration. - 10. Subretinal Iodoacetate: A Model of Retinal Degeneration in Cats. - 11. Hereditary Retinal Dystrophy of Swedish Briard Dogs: Exclusion of Six Candidate Genes by Molecular Genetic Analysis. - 12. The VPP Mouse: A Transgenic Model of Autosomal Dominant Retinitis Pigmentosa. - 13. Altered Regulation of Ion Channels in Cultured Retinal Pigment Epithelial Cells from RCS Rats. - 14. Structures of the Oligosaccharides of Rhodopsin from Normal and RCS Rats. - 15. Indocyanine Green Videoangiography in the Royal College of Surgeons Rat. - 16. Defective Choroidal Angiogenesis Precedes Retinal Pigment Epithelial Phagocytic Defect in Neonatal RCS Rats. - 17. Comparative Biology of Retinoid Deprivation and Replacement in Flies and Rodents. - 18. Rhodopsin-Dependent Models of Drosophila Photoreceptor Degeneration. - 19. Recessive Degeneration of Photoreceptor Cells Caused by Point Mutations in the Cytoplasmic Domains ofDrosophila Rhodopsin. - III. Mechanisms of Retinal Degeneration and Cell Death. - 20. Nitric Oxide-Induced Increases in Retinal cGMP: A Role in Photoreceptor Degenerations. - 21. Glycohistochemical Study of Light-Induced Retinal Degeneration: Removal System of Apoptotic Cells. - 22. Light-Induced Retinal Degeneration Is Prevented in Mice Lacking c-fos. - 23. Ischemic Neuronal Death in the Fish Retina: In Respect of Oxygen Radicals and Glutathione. - IV. Candidate Genes Cloning Mapping and Other Molecular Genetics of Retinal Degeneration. - 24. Isolation of Candidate Genes for Retinal Degenerations. - 25. Studies on the Cone Cyclic GMP-Phosphodiesterase ?' Subunit Gene. - 26. Mutations in PDE6A the Gene Encoding the a-Subunit of Rod Photoreceptor cGMP-Specific Phosphodiesterase Are Rare in Autosomal Recessive Retinitis Pigmentosa. - 27. Molecular Analysis of the Human PEDF Gene a Candidate Gene for Retinal Degeneration: Localization to 17pl3. 3. - 28. Screening of Candidate Genes on Japanese Retinal Dystrophies. - 29. Strategies for the Genetic Analysis of Autosomal Recessive Retinitis Pigmentosa in Spanish Families. - 30. Progress in Positional Cloning of RP10 (7q31. 3) RP1 (8q11q21) and VMD1 (8q24). - 31. Growth Factors in the Retina: Pigment Epithelium-Derived Factor (PEDF) Now Fine Mapped to 17pl3. 3 and Tightly Linked to the RP13 Locus. - 32. Genetic and Physical Localisation of the Gene Causing Cone-Rod Dystrophy (CORD2). - 33. Usher Syndrome Type 1C: Localization to Chromosome 11p14 and Construction of a YAC Contig. - 34. Oguchi Disease Retinitis Pigmentosa and the Phototransduction Pathway. - 35. A Patient with Progressive Retinal Degeneration Associated with Homozygous 1147delA Mutation in the Arrestin Gene. - V. Transplantation Gene Therapy and Cell Rescue. - 36. bFGF Transfected Iris Pigment Epithelial Cells Rescue Photoreceptor Cell Degeneration in RCS Rats. - 37. Transplantation of Neonatal Neural Retina in Photoreceptor Degeneration of Cats. - 38. Mechanical Aspects of Retinal Pigment Epithelial Transplantation. - 39. Midkine from Various Sources in Constant Light-Induced Photoreceptor Degeneration of the Rat. - 40. The Influence of Oxygen on the Survival and Death of Photoreceptors: Evidence from Rat and Mouse. - 41. Histological Method to Assess Photoreceptor Light Damage and Protection by Survival Factors. - VI. Structural Physiologic and Aging Correlates of Retinal Degeneration. - 42. Further Studies on the Phagocytosis of Photoreceptor Outer Segments by Rat Retinal Pigment Epithelial Cells. - 43. Purification and Characterization of Matrix Metalloproteinase-3 (Stromelysin-1) from Bovine Interphotoreceptor Matrix. - 44. Senile Retinal Deficiencies in Astrocytes and Blood Vessels. - Corresponding Authors by Chapter Number. Language: English