Life Extension B12 Elite 02419

B12 Elite60 vegetarian lozengesItem Catalog Number: 02419Two Active Forms of Vitamin B12Vitamin B12 (also called cobalamin) is a water-soluble vitamin that plays a vital role in the health of your nervous system, blood cells and even your DNA (B12 helps protect delicate parts of your chromosomes). Our B12 Elite formula includes two bioactive forms of cobalamin that make it easier for your body to absorb and access vitamin B12’s health benefits.Benefits at a GlanceNovel formula delivers two forms of bioactive B12Helps protect delicate brain cellsPromotes healthy dopamine levesEncourages healthy B12 serum levelsPromotes overall brain healthVitamin B12 is good for you. But many people don’t get sufficient B12 from their diets alone. Reasons range from age-related insufficiency to dietary intake: B12 comes primarily from animal sources, so those following a vegetarian diet may not get enough.Our new B12 Elite combines two types of cobalamin: adenosylcobalamin and methylcobalamin. These are “active” forms—meaning your body can make use of them right away.Adenosylcobalamin helps preserve neuronal functionLeucine-Rich Repeat Kinase 2 (LRRK2) is a type of enzyme that modifies other proteins by adding phosphate groups.1 Inhibiting the activity of this enzyme has been associated with helping to preserve neuronal tissue.2A series of preclinical studies has shown that the adenosylcobalamin form of B12 can inhibit the activity of multiple LRRK2 variants in neurons by decreasing phosphorylation (the addition of phosphate groups to amino acids).3These studies found that adenosylcobalamin helped regulate healthy release of dopamine, a neurotransmitter that plays an important role in cognitive functions such as motor control, arousal, reinforcement and reward.3-6A cofactor for energy metabolismAdenosylcobalamin is active in the mitochondria, the powerhouses of your cells. It’s required as a cofactor for the synthesis of succinyl-CoA, a compound that supports cellular energy metabolism.7-9Methylcobalamin for cellular health & beyondMethylcobalamin is another neurologically active form of B12 (though in different ways than adenosylcobalamin). Methylcobalamin supports the central nervous system, and it’s essential for the replication and growth of cells.10Methylcobalamin helps to maintain already healthy homocysteine levels.11-14 Inhibiting excess levels of this compound is key to maintaining healthy cardiovascular and neurological function.B12 for a healthy brain and moreThis B12 formula combines methylcobalamin and adenosylcobalamin to offer optimal cognitive support. Supplement FactsServing Size 1 vegetarian lozengeAmount Per ServingVitamin B12 (as adenosylcobalamin, methylcobalamin)1000 mgOther ingredients: maltodextrin, xylitol, l-leucine, citric acid, guar gum, beet juice, modified food starch, stevia extract, strawberry flavor.Non-GMODosage and UseDissolve in mouth or chew one (1) lozenge daily, or as recommended by a healthcare practitioner.WarningsKEEP OUT OF REACH OF CHILDRENDO NOT EXCEED RECOMMENDED DOSEDo not purchase if outer seal is broken or damaged.When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.+ References Frontiers in neuroscience. 2020;14:527-527.The Neuroscientist. 2018;24(5):486-500.Cell Res. 2019;29(4):313-329.International archives of medicine. 2010;3:24-24.International Journal of Impotence Research. 2001;13(3):S18-S28.Elife. 2017;6EFSA Journal. 2008;6(10):815.Nutrients. 2013;5(12):5031-45.Nutrients. 2010;2(3):299-316.Lancet Neurol. 2006;5(11):949-60.Chem Biol Interact. 2006;163(1-2):94-112.N. I. o. Health. Riboflavin Fact Sheet for Health Professionals. Accessed https://ods.od.nih.gov/factsheets/Riboflavin-HealthProfessional/Altern Med Rev. 2011;16(3):263-74.J Lipid Res. 2019;60(4):741-746.