Since the nineteenth century when engineers were using nitroglycerin to blow up rockbeds and doctors were prescribing it to relieve angina scientists have been exploring the incredible and often baffling behavior of nitric oxide. In the 1980s researchers discovered that nitric oxide had the capacity to regulate vascular tone through cyclic GMP firmly establishing its role as a physiological mediator. Over the last ten years still further roles have been discovered that relate to nitric oxideâs unique ability to interact with and modify a wide variety of other molecules and regulators including glutathione as well as macromolecules such as DNA and proteins. Nitric Oxide Cell Signaling and Gene Expression is the first comprehensive work to showcase the highly useful diversity of cellular effects elicited by nitric oxide. A collection of expert contributors provides cutting-edge information on a variety of topics with tremendous implications in the fields of biology and medicine. These includeâ Nitric oxide-driven cell signaling mediated by cGMP GTPases and S-nitrosylation Nitric oxideâs role in hypoxia gene expression post-transcriptional control of gene expression gene regulation in pulmonary pathophysiology and tumor biologyThe intriguing concept of mitochondrial nitric oxide synthase as a regulator of mitochondrial bioenergetics and free radical productionModulation of cell metabolism Nitric Oxide Cell Signaling and Gene Expression offers cell and molecular biologists pharmacologists biochemists and biomedical researchers as well as advanced graduate students the insight and information they need to understand recent developments in this highly fertile area of research. . Language: English