Introduction: Historical Aspects of Alkyl Lipids and Their BiologicallyActive Forms (Ether LipidsPlatelet-Activating Factor andAntihypertensive Renal Lipids). - I. Methodology and Chemistry. - 1. Chemical Synthesis and Mass Spectrometry of PAF. - 2. Chromatographic Analyses of Ether-Linked LipidsInvolved in PAF Metabolism. - II. Composition. - 3. Composition of Alkyl Ether-Linked Phospholipids in Mammalian Tissues. - III. Enzymes. - 4. Enzymatic Pathways for Platelet-Activating Factor Related Alkyl Glycerolipids their Precursors. - 5. Enzymatic Control of the Cellular Levels of Platelet-Activating Factor. - IV. Antagonists Agonists and Receptors. - 6. Platelet-Activating Factor Binding to Specific Cell Membrane Receptors. - 7. The Chemical and Biological Properties of PAF Agonists Antagonists and Biosynthetic Inhibitors. - 8. Conformational Properties of the PAF-Acether Receptor on Platelets Based on StructureActivity Studies. - V. Biochemical and Biological Aspects in Specific Cells and Tissues. - 9. Diversity of the Biochemical and Biological Behavior of Platelet-Activating Factor. - 10. Extracellular and Intracellular Activities of PAF. - 11. Interrelationships in the Metabolism of Platelet-Activating Factorand Arachidonate in Neutrophils. - 12. Platelet-Activating Factor: Mechanisms of Cellular Activation. - 13. The Role of Platelet-Activating Factor in Inflammation. - 14. The Production of Platelet-Activating Factor by Cultured Human Endothelial Cells: Regulation and Function. - 15. Bronchopulmonary Pharmacology of PAF-Acether. - 16. Platelet-Activating Factor: A Secretory Product from Phagocytes. - 17. Functions of PAF in Reproduction and Development: Involvement of PAF in Fetal Lung Maturation and Parturition. - 18. Effect of PAF on the Cardiovascular System. - 19. Biosynthesis and Release of PAF-Acether by Mouse Bone Marrow-Derived Mast Cells. - VI. Antitumor Analogs of PAF. - 20. Antineoplastic Actions of Ether Lipids Related to Platelet-Activating Factor. Language: English